I am a pharmacist with a PhD in Biochemistry from the University of Cologne, Germany, where I studied extracellular vesicles and Lyn kinase signalling in chronic lymphocytic leukaemia. My master's was on peptide-functionalised PLGA nanoparticles. I now work on single-cell and bulk transcriptomics, target prioritisation and drug repurposing in cancer, with public data and code that others can rerun.
I am also Responsible Pharmacist and Medical Affairs & Scientific Lead at a pharmaceutical company in São Paulo, and I teach in the Pharmacy programme at Afya Universidade Unigranrio.
7,186 cells from 31 tumours (GSE115978). With tumours rather than cells as replicates, only 61 of 5,384 cell-level hits hold up; EMP1 loss after treatment is the strongest signal left.
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1,908 interventional trials and 11,387 Brazilian sites from ClinicalTrials.gov. 72% are industry-sponsored and 73% multinational: a feasibility view by phase, tumour type and state.
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9,145 curated molecules (AqSolDB). XGBoost reaches RMSE 0.85 on a random split but 1.23 log units on unseen scaffolds, and error grows as similarity to the training set falls.
View analysisNextflow pipeline for gene panels: QC, alignment, per-target coverage, variant calling and annotation. Benchmarked against a truth set on every push: 131 of 132 variants recovered, the one miss flagged as low coverage.
View repositoryPatterns and patches to integrate ~486k single cells on a 16 GB laptop, with tests and a memory benchmark: centred sparse PCA adds under 200 MB, less than the uncentred shortcut.
View repositoryDownload scripts for GEO, cBioPortal and TCGA that check file sizes, record checksums and report failed files. Covered by 18 tests.
View repositoryBench tool that turns a counted cell suspension into a master-mix recipe for plates and flasks. Bilingual, with tested formulas.
Open toolTechnical responsibility, regulatory affairs and scientific content for a pharmaceutical company.
Lecturer in the online Pharmacy programme and member of the Structuring Teaching Core (NDE) for the on-campus and online courses.
Computational oncology and drug repurposing projects.
Extracellular vesicles and Lyn kinase signalling in chronic lymphocytic leukaemia.
Degree recognised in Brazil by UFRGS.
PLGA nanoparticles and peptides for drug delivery.
QC, integration of multi-cohort atlases, clustering and annotation, malignant cell states, regulon inference and differential expression, with Seurat, Scanpy, Harmony, pySCENIC and DESeq2.
Connecting expression programs to druggable targets and existing compounds using perturbation signatures, dependency screens and interaction networks.
Trial-registry analyses for feasibility, medical affairs, and regulatory work with ANVISA.
Laboratory background in EV biology, kinase signalling in leukaemia and polymeric nanoparticles.
Open to collaborations in computational oncology, postdoctoral positions and translational research roles in industry.
